Drug interactions
Dasatinib + Ethinyl estradiol-norgestimate
Severity: Minor
Dasatinib and Ethinyl estradiol-norgestimate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ethinyl estradiol is a weak CYP3A4 inhibitor and could raise dasatinib levels slightly. Dasatinib toxicity such as myelosuppression, fluid retention or QT prolongation could be increased. The clinical significance is probably small.
What this interaction means in plain words
Dasatinib and Ethinyl estradiol-norgestimate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dasatinib belongs to Oncology; Ethinyl estradiol-norgestimate belongs to Endocrine.
Why it happens
Weak inhibition of CYP3A4-mediated dasatinib metabolism by ethinyl estradiol.
What to do
No routine dose change is needed; monitor blood counts and for fluid retention as part of normal dasatinib care. Note that dasatinib is teratogenic and contraception counseling should continue.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ethinyl estradiol-norgestimate
- Ethinyl estradiol-norgestimate + Fezolinetant Contraindicated
- Ethinyl estradiol-norgestimate + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-norgestimate + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-norgestimate Major
- Amobarbital + Ethinyl estradiol-norgestimate Major
- Anastrozole + Ethinyl estradiol-norgestimate Major
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Ethinyl estradiol-norgestimate?
MediHelp rates the interaction as minor. Dasatinib and Ethinyl estradiol-norgestimate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ethinyl estradiol is a weak CYP3A4 inhibitor and could raise dasatinib levels slightly. Dasatinib toxicity such as myelosuppression, fluid retention or QT prolongation could be increased. The clinical significance is probably small.
How serious is the interaction between Dasatinib and Ethinyl estradiol-norgestimate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change is needed; monitor blood counts and for fluid retention as part of normal dasatinib care. Note that dasatinib is teratogenic and contraception counseling should continue.
What other medicines interact with Ethinyl estradiol-norgestimate?
MediHelp also lists interactions of Ethinyl estradiol-norgestimate with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir and dasabuvir, Tranexamic acid. The full list is on the Ethinyl estradiol-norgestimate page.
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