Drug interactions
Dasatinib + Fexinidazole
Severity: Major
Dasatinib and Fexinidazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fexinidazole prolongs the QT interval and inhibits CYP3A4, while dasatinib is a CYP3A4 substrate that also prolongs the QT interval. The combination may increase dasatinib exposure and add to arrhythmic risk.
What this interaction means in plain words
Dasatinib and Fexinidazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive QT prolongation plus CYP3A4 inhibition raising dasatinib concentrations.
What to do
Avoid coadministration. If fexinidazole therapy cannot be postponed, monitor the ECG and electrolytes and watch for dasatinib toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Fexinidazole?
MediHelp rates the interaction as major. Dasatinib and Fexinidazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Fexinidazole prolongs the QT interval and inhibits CYP3A4, while dasatinib is a CYP3A4 substrate that also prolongs the QT interval. The combination may increase dasatinib exposure and add to arrhythmic risk.
How serious is the interaction between Dasatinib and Fexinidazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid coadministration. If fexinidazole therapy cannot be postponed, monitor the ECG and electrolytes and watch for dasatinib toxicity.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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