Drug interactions
Dasatinib + Fosphenytoin
Severity: Major
Dasatinib and Fosphenytoin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenytoin, formed from fosphenytoin, is a strong CYP3A4 inducer and is expected to considerably lower dasatinib concentrations. This risks loss of antileukemic efficacy.
What this interaction means in plain words
Dasatinib and Fosphenytoin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dasatinib belongs to Oncology; Fosphenytoin belongs to Central Nervous System.
Why it happens
Phenytoin induces CYP3A4, increasing dasatinib metabolism.
What to do
Avoid and use a non-inducing anticonvulsant such as levetiracetam. If unavoidable, increase the dasatinib dose with close monitoring of response and toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Fosphenytoin
- Dronedarone + Fosphenytoin Contraindicated
- Fosphenytoin + Ledipasvir-sofosbuvir Contraindicated
- Fosphenytoin + Lorlatinib Contraindicated
- Fosphenytoin + Lurasidone Contraindicated
- Fosphenytoin + Ranolazine Contraindicated
- Fosphenytoin + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
Frequently asked questions
Can I take Dasatinib with Fosphenytoin?
MediHelp rates the interaction as major. Dasatinib and Fosphenytoin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Phenytoin, formed from fosphenytoin, is a strong CYP3A4 inducer and is expected to considerably lower dasatinib concentrations. This risks loss of antileukemic efficacy.
How serious is the interaction between Dasatinib and Fosphenytoin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid and use a non-inducing anticonvulsant such as levetiracetam. If unavoidable, increase the dasatinib dose with close monitoring of response and toxicity.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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