Drug interactions
Dasatinib + Glimepiride-pioglitazone
Severity: Minor
Dasatinib and Glimepiride-pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib inhibits CYP3A4 weakly and is unlikely to change pioglitazone exposure meaningfully. Dasatinib has also been linked to variable glucose effects, so glycemic control may shift.
What this interaction means in plain words
Dasatinib and Glimepiride-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dasatinib belongs to Oncology; Glimepiride-pioglitazone belongs to Endocrine.
Why it happens
Weak CYP3A4 inhibition affecting a minor pioglitazone pathway; direct glucose effects are not well characterized.
What to do
No dose change is needed; monitor blood glucose during dasatinib therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Glimepiride-pioglitazone?
MediHelp rates the interaction as minor. Dasatinib and Glimepiride-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dasatinib inhibits CYP3A4 weakly and is unlikely to change pioglitazone exposure meaningfully. Dasatinib has also been linked to variable glucose effects, so glycemic control may shift.
How serious is the interaction between Dasatinib and Glimepiride-pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed; monitor blood glucose during dasatinib therapy.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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