Drug interactions
Dasatinib + Hydrocortisone
Severity: Minor
Dasatinib and Hydrocortisone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib is a CYP3A4 substrate and weak inhibitor, and hydrocortisone a weak inducer, so effects on either drug are likely small. Corticosteroids and dasatinib may also both contribute to fluid retention or infection risk.
What this interaction means in plain words
Dasatinib and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dasatinib belongs to Oncology; Hydrocortisone belongs to Endocrine.
Why it happens
Weak bidirectional CYP3A4 effects, not established as clinically significant.
What to do
No dose adjustment is needed; monitor for fluid retention and dasatinib response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Hydrocortisone?
MediHelp rates the interaction as minor. Dasatinib and Hydrocortisone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dasatinib is a CYP3A4 substrate and weak inhibitor, and hydrocortisone a weak inducer, so effects on either drug are likely small. Corticosteroids and dasatinib may also both contribute to fluid retention or infection risk.
How serious is the interaction between Dasatinib and Hydrocortisone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed; monitor for fluid retention and dasatinib response.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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