Drug interactions
Dasatinib + Ibuprofen / famotidine
Severity: Major
Dasatinib and Ibuprofen / famotidine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib absorption depends on an acidic gastric environment, and famotidine, an H2 blocker, raises gastric pH. This can substantially reduce dasatinib exposure and may compromise the response to treatment.
What this interaction means in plain words
Dasatinib and Ibuprofen / famotidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Higher gastric pH from famotidine reduces the dissolution and absorption of dasatinib.
What to do
Avoid H2 antagonists with dasatinib and use an antacid instead, giving it at least 2 hours before or after dasatinib. Use a separate ibuprofen product if an NSAID is needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Ibuprofen / famotidine?
MediHelp rates the interaction as major. Dasatinib and Ibuprofen / famotidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dasatinib absorption depends on an acidic gastric environment, and famotidine, an H2 blocker, raises gastric pH. This can substantially reduce dasatinib exposure and may compromise the response to treatment.
How serious is the interaction between Dasatinib and Ibuprofen / famotidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid H2 antagonists with dasatinib and use an antacid instead, giving it at least 2 hours before or after dasatinib. Use a separate ibuprofen product if an NSAID is needed.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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