Drug interactions
Dasatinib + Inotuzumab
Severity: Major
Dasatinib and Inotuzumab: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Inotuzumab ozogamicin and dasatinib can each prolong the QT interval. Combined use may increase the chance of arrhythmia, and inotuzumab also carries hepatotoxicity concerns.
What this interaction means in plain words
Dasatinib and Inotuzumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Obtain a baseline ECG and electrolytes and repeat the ECG during treatment. Correct potassium and magnesium, and review the need for other QT-prolonging drugs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Inotuzumab?
MediHelp rates the interaction as major. Dasatinib and Inotuzumab can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Inotuzumab ozogamicin and dasatinib can each prolong the QT interval. Combined use may increase the chance of arrhythmia, and inotuzumab also carries hepatotoxicity concerns.
How serious is the interaction between Dasatinib and Inotuzumab?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and electrolytes and repeat the ECG during treatment. Correct potassium and magnesium, and review the need for other QT-prolonging drugs.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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