Drug interactions
Dasatinib + Isoniazid
Severity: Moderate
Dasatinib and Isoniazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib is a CYP3A4 substrate, and isoniazid may inhibit this enzyme weakly. Dasatinib levels could rise, increasing myelosuppression, fluid retention and QT effects. Both drugs can also affect the liver.
What this interaction means in plain words
Dasatinib and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Isoniazid belongs to Anti Bacterial.
Why it happens
Isoniazid-mediated CYP3A4 inhibition may reduce dasatinib clearance.
What to do
Monitor blood counts, liver tests and ECG during co-use. Reduce the dasatinib dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Isoniazid
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Isoniazid?
MediHelp rates the interaction as moderate. Dasatinib and Isoniazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dasatinib is a CYP3A4 substrate, and isoniazid may inhibit this enzyme weakly. Dasatinib levels could rise, increasing myelosuppression, fluid retention and QT effects. Both drugs can also affect the liver.
How serious is the interaction between Dasatinib and Isoniazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts, liver tests and ECG during co-use. Reduce the dasatinib dose if adverse effects occur.
What other medicines interact with Isoniazid?
MediHelp also lists interactions of Isoniazid with, for example, Bacillus calmette-guerin substrain tice, Benzhydrocodone / acetaminophen, Carbamazepine. The full list is on the Isoniazid page.
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