Drug interactions
Dasatinib + Isradipine
Severity: Minor
Dasatinib and Isradipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Isradipine is a CYP3A4 substrate, and dasatinib may increase its levels. This may enhance hypotension, flushing, edema and reflex tachycardia.
What this interaction means in plain words
Dasatinib and Isradipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Dasatinib inhibits CYP3A4, reducing isradipine first-pass and systemic metabolism.
What to do
Monitor blood pressure and heart rate when starting dasatinib. Lower the isradipine dose if hypotension or marked edema develops.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Isradipine?
MediHelp rates the interaction as minor. Dasatinib and Isradipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Isradipine is a CYP3A4 substrate, and dasatinib may increase its levels. This may enhance hypotension, flushing, edema and reflex tachycardia.
How serious is the interaction between Dasatinib and Isradipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when starting dasatinib. Lower the isradipine dose if hypotension or marked edema develops.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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