Drug interactions
Dasatinib + Ixabepilone
Severity: Minor
Dasatinib and Ixabepilone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib is a weak CYP3A4 inhibitor and could modestly increase ixabepilone exposure. Clinical impact is uncertain but ixabepilone toxicity includes neuropathy and myelosuppression.
What this interaction means in plain words
Dasatinib and Ixabepilone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP3A4 inhibition by dasatinib reducing ixabepilone metabolism.
What to do
Monitor blood counts and neuropathy symptoms; no preemptive dose change is generally needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Ixabepilone?
MediHelp rates the interaction as minor. Dasatinib and Ixabepilone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dasatinib is a weak CYP3A4 inhibitor and could modestly increase ixabepilone exposure. Clinical impact is uncertain but ixabepilone toxicity includes neuropathy and myelosuppression.
How serious is the interaction between Dasatinib and Ixabepilone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and neuropathy symptoms; no preemptive dose change is generally needed.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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