Drug interactions
Dasatinib + Lithium
Severity: Moderate
Dasatinib and Lithium: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been associated with QT interval prolongation, so their combination may increase the risk of torsades de pointes, especially with electrolyte disturbances or other risk factors. Lithium toxicity or electrolyte shifts could add to the risk.
What this interaction means in plain words
Dasatinib and Lithium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Lithium belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effect on cardiac repolarization.
What to do
Obtain a baseline ECG and correct potassium and magnesium before starting. Monitor QTc periodically and keep lithium levels in the therapeutic range.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lithium
- Lithium + Thioridazine Contraindicated
- Lithium + Vandetanib Contraindicated
- Aceclofenac + Lithium Major
- Acemetacin + Lithium Major
- Amisulpride + Lithium Major
- Amlodipine-benazepril + Lithium Major
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Lithium?
MediHelp rates the interaction as moderate. Dasatinib and Lithium can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs have been associated with QT interval prolongation, so their combination may increase the risk of torsades de pointes, especially with electrolyte disturbances or other risk factors. Lithium toxicity or electrolyte shifts could add to the risk.
How serious is the interaction between Dasatinib and Lithium?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before starting. Monitor QTc periodically and keep lithium levels in the therapeutic range.
What other medicines interact with Lithium?
MediHelp also lists interactions of Lithium with, for example, Thioridazine, Vandetanib, Aceclofenac. The full list is on the Lithium page.
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