Drug interactions
Dasatinib + Nirmatrelvir / ritonavir
Severity: Major
Dasatinib and Nirmatrelvir / ritonavir: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir-boosted nirmatrelvir strongly inhibits CYP3A4 and can markedly raise dasatinib levels. This increases risk of myelosuppression, fluid retention and QT prolongation.
What this interaction means in plain words
Dasatinib and Nirmatrelvir / ritonavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Ritonavir and nirmatrelvir inhibit CYP3A4, reducing dasatinib clearance.
What to do
Hold dasatinib or reduce its dose during the course and for a few days afterward as per labeling, and monitor blood counts and ECG.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Nirmatrelvir / ritonavir?
MediHelp rates the interaction as major. Dasatinib and Nirmatrelvir / ritonavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ritonavir-boosted nirmatrelvir strongly inhibits CYP3A4 and can markedly raise dasatinib levels. This increases risk of myelosuppression, fluid retention and QT prolongation.
How serious is the interaction between Dasatinib and Nirmatrelvir / ritonavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Hold dasatinib or reduce its dose during the course and for a few days afterward as per labeling, and monitor blood counts and ECG.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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