Drug interactions
Dasatinib + Nirmatrelvir
Severity: Major
Dasatinib and Nirmatrelvir: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nirmatrelvir, a strong CYP3A4 inhibitor, can substantially raise dasatinib exposure, increasing risk of myelosuppression, effusions and QT prolongation.
What this interaction means in plain words
Dasatinib and Nirmatrelvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dasatinib belongs to Oncology; Nirmatrelvir belongs to Anti Virals.
Why it happens
Inhibition of CYP3A4 reduces dasatinib clearance.
What to do
Consider holding or reducing dasatinib during the short antiviral course per labeling, and monitor blood counts and toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Other interactions of Nirmatrelvir
- Alfuzosin + Nirmatrelvir Contraindicated
- Amiodarone + Nirmatrelvir Contraindicated
- Apalutamide + Nirmatrelvir Contraindicated
- Carbamazepine + Nirmatrelvir Contraindicated
- Colchicine + Nirmatrelvir Contraindicated
- Dronedarone + Nirmatrelvir Contraindicated
Frequently asked questions
Can I take Dasatinib with Nirmatrelvir?
MediHelp rates the interaction as major. Dasatinib and Nirmatrelvir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Nirmatrelvir, a strong CYP3A4 inhibitor, can substantially raise dasatinib exposure, increasing risk of myelosuppression, effusions and QT prolongation.
How serious is the interaction between Dasatinib and Nirmatrelvir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider holding or reducing dasatinib during the short antiviral course per labeling, and monitor blood counts and toxicity.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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