Drug interactions
Dasatinib + Nitrendipine
Severity: Minor
Dasatinib and Nitrendipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nitrendipine undergoes extensive CYP3A4 first-pass metabolism, so dasatinib may raise its levels. This can increase hypotension, peripheral edema and headache.
What this interaction means in plain words
Dasatinib and Nitrendipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Dasatinib inhibits CYP3A4 and reduces nitrendipine clearance.
What to do
Monitor blood pressure after starting dasatinib. Reduce the nitrendipine dose if hypotension occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Nitrendipine?
MediHelp rates the interaction as minor. Dasatinib and Nitrendipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nitrendipine undergoes extensive CYP3A4 first-pass metabolism, so dasatinib may raise its levels. This can increase hypotension, peripheral edema and headache.
How serious is the interaction between Dasatinib and Nitrendipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting dasatinib. Reduce the nitrendipine dose if hypotension occurs.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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