Drug interactions
Dasatinib + Octreotide
Severity: Moderate
Dasatinib and Octreotide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QTc interval, so combined use may add to the risk of torsades de pointes. Risk is higher with electrolyte disturbances, bradycardia or other QT-prolonging drugs.
What this interaction means in plain words
Dasatinib and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Octreotide belongs to Endocrine.
Why it happens
Additive pharmacodynamic effect on cardiac repolarization (QTc prolongation); octreotide also causes bradycardia.
What to do
Obtain a baseline ECG and monitor QTc during combined use. Correct potassium and magnesium abnormalities and avoid adding other QT-prolonging drugs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Octreotide
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Octreotide?
MediHelp rates the interaction as moderate. Dasatinib and Octreotide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QTc interval, so combined use may add to the risk of torsades de pointes. Risk is higher with electrolyte disturbances, bradycardia or other QT-prolonging drugs.
How serious is the interaction between Dasatinib and Octreotide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc during combined use. Correct potassium and magnesium abnormalities and avoid adding other QT-prolonging drugs.
What other medicines interact with Octreotide?
MediHelp also lists interactions of Octreotide with, for example, Adagrasib, Amisulpride, Arsenic trioxide. The full list is on the Octreotide page.
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