Drug interactions
Dasatinib + Ofatumumab sc
Severity: Moderate
Dasatinib and Ofatumumab sc: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib causes myelosuppression and impairs immune function, and ofatumumab depletes B cells. Taken together they may add to the risk of serious or opportunistic infections.
What this interaction means in plain words
Dasatinib and Ofatumumab sc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive immunosuppression and myelosuppression through different mechanisms (B-cell depletion plus kinase inhibitor effects on haematopoiesis and lymphocyte function).
What to do
Monitor for signs of infection and check blood counts periodically. Screen for hepatitis B before starting ofatumumab and delay or interrupt it if an active infection develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Ofatumumab sc?
MediHelp rates the interaction as moderate. Dasatinib and Ofatumumab sc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dasatinib causes myelosuppression and impairs immune function, and ofatumumab depletes B cells. Taken together they may add to the risk of serious or opportunistic infections.
How serious is the interaction between Dasatinib and Ofatumumab sc?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection and check blood counts periodically. Screen for hepatitis B before starting ofatumumab and delay or interrupt it if an active infection develops.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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