Drug interactions
Dasatinib + Olanzapine
Severity: Moderate
Dasatinib and Olanzapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib is associated with QT prolongation, and olanzapine has a low but recognised potential to prolong the QT interval. Combined use may increase the risk of ventricular arrhythmias, especially with electrolyte disturbances or underlying cardiac disease.
What this interaction means in plain words
Dasatinib and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Olanzapine belongs to Central Nervous System.
Why it happens
Additive prolongation of cardiac repolarisation (QTc) by both drugs.
What to do
Obtain a baseline ECG and correct potassium and magnesium before combining. Repeat ECG monitoring during treatment, particularly if other QT-prolonging drugs are present.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Olanzapine
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Olanzapine?
MediHelp rates the interaction as moderate. Dasatinib and Olanzapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dasatinib is associated with QT prolongation, and olanzapine has a low but recognised potential to prolong the QT interval. Combined use may increase the risk of ventricular arrhythmias, especially with electrolyte disturbances or underlying cardiac disease.
How serious is the interaction between Dasatinib and Olanzapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and correct potassium and magnesium before combining. Repeat ECG monitoring during treatment, particularly if other QT-prolonging drugs are present.
What other medicines interact with Olanzapine?
MediHelp also lists interactions of Olanzapine with, for example, Amisulpride, Amoxapine, Apomorphine. The full list is on the Olanzapine page.
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