Drug interactions
Dasatinib + Parecoxib
Severity: Moderate
Dasatinib and Parecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Parecoxib is a prodrug converted to valdecoxib, which is metabolized by CYP3A4 and CYP2C9. Dasatinib may slightly raise valdecoxib levels. Both drugs can also impair platelet function or cause bleeding, which adds to the concern.
What this interaction means in plain words
Dasatinib and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Weak CYP3A4 inhibition by dasatinib may raise valdecoxib levels, and dasatinib has additive antiplatelet and bleeding effects.
What to do
Monitor for bleeding and use the lowest effective parecoxib dose for the shortest time. Check platelet counts during treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Parecoxib?
MediHelp rates the interaction as moderate. Dasatinib and Parecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Parecoxib is a prodrug converted to valdecoxib, which is metabolized by CYP3A4 and CYP2C9. Dasatinib may slightly raise valdecoxib levels. Both drugs can also impair platelet function or cause bleeding, which adds to the concern.
How serious is the interaction between Dasatinib and Parecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and use the lowest effective parecoxib dose for the shortest time. Check platelet counts during treatment.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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