Drug interactions
Dasatinib + Phenytoin
Severity: Major
Dasatinib and Phenytoin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenytoin lowers dasatinib plasma concentrations, which may lead to subtherapeutic exposure and reduced leukemia control. Enzyme-inducing antiseizure drugs generally reduce dasatinib exposure substantially.
What this interaction means in plain words
Dasatinib and Phenytoin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dasatinib belongs to Oncology; Phenytoin belongs to Central Nervous System.
Why it happens
Phenytoin induces CYP3A4, increasing the metabolism of dasatinib.
What to do
Prefer a non-inducing antiseizure drug. If phenytoin is required, consider increasing the dasatinib dose with close monitoring for response and toxicity, and reduce the dose when phenytoin is stopped.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Phenytoin
- Artemether / lumefantrine + Phenytoin Contraindicated
- Bictegravir + Phenytoin Contraindicated
- Cabotegravir + Phenytoin Contraindicated
- Doravirine + Phenytoin Contraindicated
- Elbasvir / grazoprevir + Phenytoin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Phenytoin Contraindicated
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Phenytoin?
MediHelp rates the interaction as major. Dasatinib and Phenytoin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Phenytoin lowers dasatinib plasma concentrations, which may lead to subtherapeutic exposure and reduced leukemia control. Enzyme-inducing antiseizure drugs generally reduce dasatinib exposure substantially.
How serious is the interaction between Dasatinib and Phenytoin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-inducing antiseizure drug. If phenytoin is required, consider increasing the dasatinib dose with close monitoring for response and toxicity, and reduce the dose when phenytoin is stopped.
What other medicines interact with Phenytoin?
MediHelp also lists interactions of Phenytoin with, for example, Artemether / lumefantrine, Bictegravir, Cabotegravir. The full list is on the Phenytoin page.
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