Drug interactions
Dasatinib + Procainamide
Severity: Major
Dasatinib and Procainamide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procainamide is a class IA antiarrhythmic known to prolong the QT interval and cause torsades de pointes. With dasatinib the additive effect on repolarization raises the risk of life-threatening arrhythmia.
What this interaction means in plain words
Dasatinib and Procainamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic prolongation of the QT interval.
What to do
Use a non-QT-prolonging antiarrhythmic if possible. If the combination is necessary, monitor ECG closely and maintain normal potassium and magnesium levels.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Procainamide?
MediHelp rates the interaction as major. Dasatinib and Procainamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Procainamide is a class IA antiarrhythmic known to prolong the QT interval and cause torsades de pointes. With dasatinib the additive effect on repolarization raises the risk of life-threatening arrhythmia.
How serious is the interaction between Dasatinib and Procainamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-QT-prolonging antiarrhythmic if possible. If the combination is necessary, monitor ECG closely and maintain normal potassium and magnesium levels.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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