Drug interactions
Dasatinib + Romidepsin
Severity: Moderate
Dasatinib and Romidepsin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib may moderately inhibit CYP3A4 and raise romidepsin exposure, and both drugs can prolong the QT interval. The combination could increase the risk of romidepsin toxicity and of arrhythmia.
What this interaction means in plain words
Dasatinib and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP3A4 inhibition by dasatinib reduces romidepsin clearance, with additive QT prolongation.
What to do
Monitor ECG and electrolytes, correcting potassium and magnesium before each romidepsin dose. Watch for increased romidepsin adverse effects such as cytopenias and nausea.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Romidepsin?
MediHelp rates the interaction as moderate. Dasatinib and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dasatinib may moderately inhibit CYP3A4 and raise romidepsin exposure, and both drugs can prolong the QT interval. The combination could increase the risk of romidepsin toxicity and of arrhythmia.
How serious is the interaction between Dasatinib and Romidepsin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG and electrolytes, correcting potassium and magnesium before each romidepsin dose. Watch for increased romidepsin adverse effects such as cytopenias and nausea.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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