Drug interactions
Dasatinib + Sodium citrate / citric acid
Severity: Moderate
Dasatinib and Sodium citrate / citric acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sodium citrate neutralizes gastric acid and can raise gastric pH, which may reduce dasatinib dissolution and absorption. The effect is transient but could lower exposure if taken close to dasatinib.
What this interaction means in plain words
Dasatinib and Sodium citrate / citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Transient rise in gastric pH decreases absorption of pH-dependent dasatinib.
What to do
Separate administration so the citrate preparation is taken at least 2 hours before or after dasatinib. Monitor treatment response if used regularly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Sodium citrate / citric acid?
MediHelp rates the interaction as moderate. Dasatinib and Sodium citrate / citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sodium citrate neutralizes gastric acid and can raise gastric pH, which may reduce dasatinib dissolution and absorption. The effect is transient but could lower exposure if taken close to dasatinib.
How serious is the interaction between Dasatinib and Sodium citrate / citric acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Separate administration so the citrate preparation is taken at least 2 hours before or after dasatinib. Monitor treatment response if used regularly.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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