Drug interactions
Dasatinib + Triazolam
Severity: Moderate
Dasatinib and Triazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triazolam is a sensitive CYP3A4 substrate, and dasatinib can inhibit CYP3A4. Triazolam levels may increase, causing deeper sedation, confusion and psychomotor impairment.
What this interaction means in plain words
Dasatinib and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP3A4-mediated triazolam metabolism by dasatinib.
What to do
Use the lowest effective triazolam dose and monitor for excessive sedation. Consider a benzodiazepine not dependent on CYP3A4, such as temazepam or lorazepam.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Triazolam?
MediHelp rates the interaction as moderate. Dasatinib and Triazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triazolam is a sensitive CYP3A4 substrate, and dasatinib can inhibit CYP3A4. Triazolam levels may increase, causing deeper sedation, confusion and psychomotor impairment.
How serious is the interaction between Dasatinib and Triazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective triazolam dose and monitor for excessive sedation. Consider a benzodiazepine not dependent on CYP3A4, such as temazepam or lorazepam.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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