Drug interactions
Dasatinib + Tropisetron
Severity: Moderate
Dasatinib and Tropisetron: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib and tropisetron can each prolong the QT interval. The combination may increase the risk of ventricular arrhythmias, particularly in patients with other risk factors.
What this interaction means in plain words
Dasatinib and Tropisetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation through effects on cardiac repolarisation.
What to do
Check ECG and electrolytes before use in patients with cardiac risk factors. Consider an antiemetic with less QT effect if the QTc is already prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Tropisetron?
MediHelp rates the interaction as moderate. Dasatinib and Tropisetron can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dasatinib and tropisetron can each prolong the QT interval. The combination may increase the risk of ventricular arrhythmias, particularly in patients with other risk factors.
How serious is the interaction between Dasatinib and Tropisetron?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check ECG and electrolytes before use in patients with cardiac risk factors. Consider an antiemetic with less QT effect if the QTc is already prolonged.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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