Drug interactions
Dasatinib + Umeclidinium bromide / vilanterol inhaled
Severity: Moderate
Dasatinib and Umeclidinium bromide / vilanterol inhaled: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vilanterol, a long-acting beta agonist, can prolong the QT interval and cause tachyarrhythmias, and dasatinib may add to QT effects. Systemic exposure from inhalation is low, so the risk is modest but greater in patients with cardiac disease.
What this interaction means in plain words
Dasatinib and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation and beta-adrenergic cardiac effects.
What to do
The combination can be used if needed, with baseline ECG and monitoring in patients with cardiac risk factors. Correct hypokalemia and avoid exceeding the recommended inhaler dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Umeclidinium bromide / vilanterol inhaled?
MediHelp rates the interaction as moderate. Dasatinib and Umeclidinium bromide / vilanterol inhaled can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vilanterol, a long-acting beta agonist, can prolong the QT interval and cause tachyarrhythmias, and dasatinib may add to QT effects. Systemic exposure from inhalation is low, so the risk is modest but greater in patients with cardiac disease.
How serious is the interaction between Dasatinib and Umeclidinium bromide / vilanterol inhaled?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: The combination can be used if needed, with baseline ECG and monitoring in patients with cardiac risk factors. Correct hypokalemia and avoid exceeding the recommended inhaler dose.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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