Drug interactions
Dasatinib + Venlafaxine
Severity: Moderate
Dasatinib and Venlafaxine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib can prolong the QT interval, and venlafaxine has been associated with QT prolongation, mainly in overdose or at high doses. Together they may increase the risk of arrhythmia, particularly in patients with electrolyte disturbances or heart disease.
What this interaction means in plain words
Dasatinib and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dasatinib belongs to Oncology; Venlafaxine belongs to Central Nervous System.
Why it happens
Additive QT interval prolongation.
What to do
Check baseline ECG and correct potassium and magnesium before and during therapy. Monitor the QTc periodically and use the lowest effective venlafaxine dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Venlafaxine
- Isocarboxazid + Venlafaxine Contraindicated
- Methylene blue + Venlafaxine Contraindicated
- Phenelzine + Venlafaxine Contraindicated
- Procarbazine + Venlafaxine Contraindicated
- Rasagiline + Venlafaxine Contraindicated
- Safinamide + Venlafaxine Contraindicated
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Venlafaxine?
MediHelp rates the interaction as moderate. Dasatinib and Venlafaxine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dasatinib can prolong the QT interval, and venlafaxine has been associated with QT prolongation, mainly in overdose or at high doses. Together they may increase the risk of arrhythmia, particularly in patients with electrolyte disturbances or heart disease.
How serious is the interaction between Dasatinib and Venlafaxine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and correct potassium and magnesium before and during therapy. Monitor the QTc periodically and use the lowest effective venlafaxine dose.
What other medicines interact with Venlafaxine?
MediHelp also lists interactions of Venlafaxine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Venlafaxine page.
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