Drug interactions
Dasatinib + Vincristine liposomal
Severity: Moderate
Dasatinib and Vincristine liposomal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vincristine is metabolized by CYP3A4, and dasatinib may modestly raise its exposure. Higher levels could worsen neurotoxicity, including peripheral neuropathy and constipation or ileus.
What this interaction means in plain words
Dasatinib and Vincristine liposomal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Weak CYP3A4 inhibition by dasatinib may reduce vincristine clearance.
What to do
Monitor for neuropathy and constipation. Reduce or hold the vincristine dose if neurotoxicity develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Vincristine liposomal?
MediHelp rates the interaction as moderate. Dasatinib and Vincristine liposomal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vincristine is metabolized by CYP3A4, and dasatinib may modestly raise its exposure. Higher levels could worsen neurotoxicity, including peripheral neuropathy and constipation or ileus.
How serious is the interaction between Dasatinib and Vincristine liposomal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for neuropathy and constipation. Reduce or hold the vincristine dose if neurotoxicity develops.
What other medicines interact with Dasatinib?
MediHelp also lists interactions of Dasatinib with, for example, Saquinavir, Thioridazine, Adagrasib. The full list is on the Dasatinib page.
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