Drug interactions
Dasatinib + Zaleplon
Severity: Minor
Dasatinib and Zaleplon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasatinib is a weak CYP3A4 inhibitor and could slightly raise zaleplon levels. Since zaleplon relies mainly on aldehyde oxidase, the clinical effect is expected to be small.
What this interaction means in plain words
Dasatinib and Zaleplon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dasatinib belongs to Oncology; Zaleplon belongs to Central Nervous System.
Why it happens
Weak inhibition of CYP3A4 by dasatinib reduces the minor oxidative clearance of zaleplon.
What to do
No dose change is generally needed; observe for increased sedation or next-day drowsiness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zaleplon
- Calcium / magnesium / potassium / sodium oxybates + Zaleplon Contraindicated
- Sodium oxybate + Zaleplon Contraindicated
- Brexanolone + Zaleplon Major
- Buprenorphine long-acting + Zaleplon Major
- Buprenorphine subdermal implant + Zaleplon Major
- Buprenorphine transdermal + Zaleplon Major
Other interactions of Dasatinib
- Dasatinib + Saquinavir Contraindicated
- Dasatinib + Thioridazine Contraindicated
- Adagrasib + Dasatinib Major
- Amiodarone + Dasatinib Major
- Amisulpride + Dasatinib Major
- Amitriptyline + Dasatinib Major
Frequently asked questions
Can I take Dasatinib with Zaleplon?
MediHelp rates the interaction as minor. Dasatinib and Zaleplon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dasatinib is a weak CYP3A4 inhibitor and could slightly raise zaleplon levels. Since zaleplon relies mainly on aldehyde oxidase, the clinical effect is expected to be small.
How serious is the interaction between Dasatinib and Zaleplon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; observe for increased sedation or next-day drowsiness.
What other medicines interact with Zaleplon?
MediHelp also lists interactions of Zaleplon with, for example, Calcium / magnesium / potassium / sodium oxybates, Sodium oxybate, Brexanolone. The full list is on the Zaleplon page.
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