Drug interactions
Daunorubicin + Erythromycin
Severity: Moderate
Daunorubicin and Erythromycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Erythromycin may increase daunorubicin exposure by limiting its efflux, which could heighten myelosuppression and cardiotoxicity. Clinical data are limited.
What this interaction means in plain words
Daunorubicin and Erythromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daunorubicin belongs to Oncology; Erythromycin belongs to Anti Bacterial.
Why it happens
Inhibition of P-glycoprotein-mediated efflux of daunorubicin.
What to do
Monitor blood counts and cardiac function; prefer a non-inhibiting antibiotic if one is suitable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Erythromycin
- Conivaptan + Erythromycin Contraindicated
- Dihydroergotamine intranasal + Erythromycin Contraindicated
- Dihydroergotamine + Erythromycin Contraindicated
- Domperidone + Erythromycin Contraindicated
- Dronedarone + Erythromycin Contraindicated
- Droperidol + Erythromycin Contraindicated
Other interactions of Daunorubicin
- Adenovirus types 4 and 7 live + Daunorubicin Contraindicated
- Belatacept + Daunorubicin Major
- Cyclosporine + Daunorubicin Major
- Cyclosporin + Daunorubicin Major
- Daunorubicin + Dengue vaccine Major
- Daunorubicin + Etrasimod Major
Frequently asked questions
Can I take Daunorubicin with Erythromycin?
MediHelp rates the interaction as moderate. Daunorubicin and Erythromycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Erythromycin may increase daunorubicin exposure by limiting its efflux, which could heighten myelosuppression and cardiotoxicity. Clinical data are limited.
How serious is the interaction between Daunorubicin and Erythromycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac function; prefer a non-inhibiting antibiotic if one is suitable.
What other medicines interact with Erythromycin?
MediHelp also lists interactions of Erythromycin with, for example, Conivaptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Erythromycin page.
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