Drug interactions
Daunorubicin + Verapamil
Severity: Moderate
Daunorubicin and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil inhibits P-glycoprotein and can increase intracellular accumulation and exposure of daunorubicin. This may heighten myelosuppression and cardiotoxicity. The effect has been explored experimentally as a way to reverse multidrug resistance.
What this interaction means in plain words
Daunorubicin and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Daunorubicin belongs to Oncology; Verapamil belongs to Cardiovascular.
Why it happens
Verapamil inhibits P-glycoprotein efflux of daunorubicin, increasing tissue exposure.
What to do
Monitor blood counts and cardiac function (LVEF) closely during combined use. Consider an alternative antihypertensive or antiarrhythmic agent if cardiac risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Daunorubicin
- Adenovirus types 4 and 7 live + Daunorubicin Contraindicated
- Belatacept + Daunorubicin Major
- Cyclosporin + Daunorubicin Major
- Daunorubicin + Dengue vaccine Major
- Daunorubicin + Etrasimod Major
- Daunorubicin + Fingolimod Major
Frequently asked questions
Can I take Daunorubicin with Verapamil?
MediHelp rates the interaction as moderate. Daunorubicin and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Verapamil inhibits P-glycoprotein and can increase intracellular accumulation and exposure of daunorubicin. This may heighten myelosuppression and cardiotoxicity. The effect has been explored experimentally as a way to reverse multidrug resistance.
How serious is the interaction between Daunorubicin and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and cardiac function (LVEF) closely during combined use. Consider an alternative antihypertensive or antiarrhythmic agent if cardiac risk is high.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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