Drug interactions
Deferasirox + Ethinyl estradiol-drospirenone
Severity: Moderate
Deferasirox and Ethinyl estradiol-drospirenone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox may lower ethinyl estradiol exposure, possibly reducing contraceptive efficacy. Labeling advises caution with hormonal contraceptives for this reason.
What this interaction means in plain words
Deferasirox and Ethinyl estradiol-drospirenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferasirox belongs to Miscellaneous; Ethinyl estradiol-drospirenone belongs to Endocrine.
Why it happens
Deferasirox may induce CYP3A4 or UGT-mediated metabolism of ethinyl estradiol, lowering its concentrations.
What to do
Advise an additional non-hormonal contraceptive method during deferasirox therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ethinyl estradiol-drospirenone
- Ethinyl estradiol-drospirenone + Fezolinetant Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir Contraindicated
- Ethinyl estradiol-drospirenone + Ombitasvir / paritaprevir / ritonavir and dasabuvir Contraindicated
- Ethinyl estradiol-drospirenone + Tranexamic acid Contraindicated
- Aminocaproic acid + Ethinyl estradiol-drospirenone Major
- Amobarbital + Ethinyl estradiol-drospirenone Major
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Ethinyl estradiol-drospirenone?
MediHelp rates the interaction as moderate. Deferasirox and Ethinyl estradiol-drospirenone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox may lower ethinyl estradiol exposure, possibly reducing contraceptive efficacy. Labeling advises caution with hormonal contraceptives for this reason.
How serious is the interaction between Deferasirox and Ethinyl estradiol-drospirenone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise an additional non-hormonal contraceptive method during deferasirox therapy.
What other medicines interact with Ethinyl estradiol-drospirenone?
MediHelp also lists interactions of Ethinyl estradiol-drospirenone with, for example, Fezolinetant, Ombitasvir / paritaprevir / ritonavir, Ombitasvir / paritaprevir / ritonavir and dasabuvir. The full list is on the Ethinyl estradiol-drospirenone page.
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