Drug interactions
Deferasirox + Etonogestrel
Severity: Moderate
Deferasirox and Etonogestrel: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox can induce CYP3A4 and may reduce exposure of CYP3A4 substrates, including hormonal contraceptives. Contraceptive efficacy could be reduced, though the data are limited.
What this interaction means in plain words
Deferasirox and Etonogestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferasirox belongs to Miscellaneous; Etonogestrel belongs to Endocrine.
Why it happens
Deferasirox may induce CYP3A4 and reduce etonogestrel concentrations.
What to do
Add a barrier method or consider a non-hormonal contraceptive such as a copper IUD during deferasirox therapy. Monitor for breakthrough bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Etonogestrel
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Etonogestrel?
MediHelp rates the interaction as moderate. Deferasirox and Etonogestrel can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox can induce CYP3A4 and may reduce exposure of CYP3A4 substrates, including hormonal contraceptives. Contraceptive efficacy could be reduced, though the data are limited.
How serious is the interaction between Deferasirox and Etonogestrel?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Add a barrier method or consider a non-hormonal contraceptive such as a copper IUD during deferasirox therapy. Monitor for breakthrough bleeding.
What other medicines interact with Etonogestrel?
MediHelp also lists interactions of Etonogestrel with, for example, Amobarbital, Armodafinil, Bosentan. The full list is on the Etonogestrel page.
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