Drug interactions
Deferasirox + Fluvoxamine
Severity: Minor
Deferasirox and Fluvoxamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox can inhibit CYP1A2 and may raise exposure to CYP1A2 substrates, but fluvoxamine's clearance depends on CYP2D6 and CYP1A2 only partly. The expected increase in fluvoxamine levels is modest.
What this interaction means in plain words
Deferasirox and Fluvoxamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Deferasirox belongs to Miscellaneous; Fluvoxamine belongs to Central Nervous System.
Why it happens
Deferasirox moderately inhibits CYP1A2, which contributes to fluvoxamine metabolism.
What to do
No dose adjustment is usually required; monitor for fluvoxamine adverse effects such as nausea, somnolence or agitation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Fluvoxamine?
MediHelp rates the interaction as minor. Deferasirox and Fluvoxamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Deferasirox can inhibit CYP1A2 and may raise exposure to CYP1A2 substrates, but fluvoxamine's clearance depends on CYP2D6 and CYP1A2 only partly. The expected increase in fluvoxamine levels is modest.
How serious is the interaction between Deferasirox and Fluvoxamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually required; monitor for fluvoxamine adverse effects such as nausea, somnolence or agitation.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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