Drug interactions
Deferasirox + Fondaparinux
Severity: Moderate
Deferasirox and Fondaparinux: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox has been associated with gastric ulceration and gastrointestinal hemorrhage, and an anticoagulant increases the chance that such lesions bleed seriously. Patients with low platelet counts are at particular risk.
What this interaction means in plain words
Deferasirox and Fondaparinux can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferasirox belongs to Miscellaneous; Fondaparinux belongs to Cardiovascular.
Why it happens
Additive bleeding risk from deferasirox-related GI mucosal injury combined with fondaparinux anticoagulation.
What to do
Monitor for GI bleeding symptoms and platelet counts. Consider gastroprotection in at-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fondaparinux
- Defibrotide + Fondaparinux Contraindicated
- Fondaparinux + Ketorolac Contraindicated
- Abciximab + Fondaparinux Major
- Aceclofenac + Fondaparinux Major
- Acetylsalicylic acid + Fondaparinux Major
- Alteplase + Fondaparinux Major
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Fondaparinux?
MediHelp rates the interaction as moderate. Deferasirox and Fondaparinux can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox has been associated with gastric ulceration and gastrointestinal hemorrhage, and an anticoagulant increases the chance that such lesions bleed seriously. Patients with low platelet counts are at particular risk.
How serious is the interaction between Deferasirox and Fondaparinux?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for GI bleeding symptoms and platelet counts. Consider gastroprotection in at-risk patients.
What other medicines interact with Fondaparinux?
MediHelp also lists interactions of Fondaparinux with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Fondaparinux page.
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