Drug interactions
Deferasirox + Gentamicin
Severity: Major
Deferasirox and Gentamicin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox can cause renal impairment, including acute kidney injury, and gentamicin is nephrotoxic. Together the risk of kidney damage is increased, and impaired clearance can lead to higher aminoglycoside levels and ototoxicity.
What this interaction means in plain words
Deferasirox and Gentamicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Deferasirox belongs to Miscellaneous; Gentamicin belongs to Anti Bacterial.
Why it happens
Additive nephrotoxicity from separate renal tubular effects of both drugs.
What to do
Monitor serum creatinine or creatinine clearance frequently, and reduce or interrupt deferasirox if renal function worsens. Use gentamicin levels to guide dosing or choose a non-nephrotoxic alternative.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Gentamicin?
MediHelp rates the interaction as major. Deferasirox and Gentamicin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Deferasirox can cause renal impairment, including acute kidney injury, and gentamicin is nephrotoxic. Together the risk of kidney damage is increased, and impaired clearance can lead to higher aminoglycoside levels and ototoxicity.
How serious is the interaction between Deferasirox and Gentamicin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine or creatinine clearance frequently, and reduce or interrupt deferasirox if renal function worsens. Use gentamicin levels to guide dosing or choose a non-nephrotoxic alternative.
What other medicines interact with Gentamicin?
MediHelp also lists interactions of Gentamicin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Gentamicin page.
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