Drug interactions
Deferasirox + Itraconazole
Severity: Minor
Deferasirox and Itraconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox may lower itraconazole exposure, potentially reducing antifungal efficacy. The effect is inferred from deferasirox's mild inducing activity on metabolic enzymes.
What this interaction means in plain words
Deferasirox and Itraconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Deferasirox belongs to Miscellaneous; Itraconazole belongs to Anti Fungals.
Why it happens
Deferasirox may induce CYP3A4 and thereby accelerate itraconazole metabolism, though the effect is not well characterized.
What to do
Monitor clinical response and itraconazole trough concentrations in patients with serious fungal infections.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Itraconazole
- Alfuzosin + Itraconazole Contraindicated
- Alprazolam + Itraconazole Contraindicated
- Avanafil + Itraconazole Contraindicated
- Conivaptan + Itraconazole Contraindicated
- Dihydroergotamine intranasal + Itraconazole Contraindicated
- Dihydroergotamine + Itraconazole Contraindicated
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Itraconazole?
MediHelp rates the interaction as minor. Deferasirox and Itraconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Deferasirox may lower itraconazole exposure, potentially reducing antifungal efficacy. The effect is inferred from deferasirox's mild inducing activity on metabolic enzymes.
How serious is the interaction between Deferasirox and Itraconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and itraconazole trough concentrations in patients with serious fungal infections.
What other medicines interact with Itraconazole?
MediHelp also lists interactions of Itraconazole with, for example, Alfuzosin, Alprazolam, Avanafil. The full list is on the Itraconazole page.
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