Drug interactions
Deferasirox + Lovastatin
Severity: Moderate
Deferasirox and Lovastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox has variable effects on CYP3A4 and may lower exposure to CYP3A4 substrates such as midazolam. Lovastatin levels could fall and reduce its cholesterol-lowering effect. The clinical impact is not well characterised.
What this interaction means in plain words
Deferasirox and Lovastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferasirox belongs to Miscellaneous; Lovastatin belongs to Cardiovascular.
Why it happens
Deferasirox may induce CYP3A4-mediated metabolism of lovastatin, lowering its exposure.
What to do
Monitor the lipid profile and adjust the lovastatin dose if the response is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Deferasirox and Lovastatin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Lovastatin
- Atazanavir + Lovastatin Contraindicated
- Clarithromycin + Lovastatin Contraindicated
- Cobicistat + Lovastatin Contraindicated
- Conivaptan + Lovastatin Contraindicated
- Darunavir + Lovastatin Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Lovastatin Contraindicated
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Lovastatin?
MediHelp rates the interaction as moderate. Deferasirox and Lovastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox has variable effects on CYP3A4 and may lower exposure to CYP3A4 substrates such as midazolam. Lovastatin levels could fall and reduce its cholesterol-lowering effect. The clinical impact is not well characterised.
How serious is the interaction between Deferasirox and Lovastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor the lipid profile and adjust the lovastatin dose if the response is inadequate.
What other medicines interact with Lovastatin?
MediHelp also lists interactions of Lovastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Lovastatin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
