Drug interactions
Deferasirox + Midazolam
Severity: Moderate
Deferasirox and Midazolam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox can induce CYP3A4 and lower midazolam exposure, which may reduce its effect. Deferasirox may also inhibit CYP2C8, but this is less relevant for midazolam.
What this interaction means in plain words
Deferasirox and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferasirox belongs to Miscellaneous; Midazolam belongs to Central Nervous System.
Why it happens
Deferasirox induction of CYP3A4 increases midazolam clearance.
What to do
Monitor clinical response to midazolam and titrate to effect, anticipating higher dose requirements. Reassess when deferasirox is started or stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Midazolam
- Atazanavir + Midazolam Contraindicated
- Cobicistat + Midazolam Contraindicated
- Darunavir + Midazolam Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Midazolam Contraindicated
- Fosamprenavir + Midazolam Contraindicated
- Indinavir + Midazolam Contraindicated
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Midazolam?
MediHelp rates the interaction as moderate. Deferasirox and Midazolam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox can induce CYP3A4 and lower midazolam exposure, which may reduce its effect. Deferasirox may also inhibit CYP2C8, but this is less relevant for midazolam.
How serious is the interaction between Deferasirox and Midazolam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to midazolam and titrate to effect, anticipating higher dose requirements. Reassess when deferasirox is started or stopped.
What other medicines interact with Midazolam?
MediHelp also lists interactions of Midazolam with, for example, Atazanavir, Cobicistat, Darunavir. The full list is on the Midazolam page.
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