Drug interactions
Deferasirox + Nabumetone
Severity: Major
Deferasirox and Nabumetone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause gastrointestinal ulceration and bleeding, and deferasirox also carries risks of renal and hepatic toxicity. Combined use raises the likelihood of serious gastrointestinal hemorrhage and renal injury.
What this interaction means in plain words
Deferasirox and Nabumetone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Deferasirox belongs to Miscellaneous; Nabumetone belongs to Musculoskeletal.
Why it happens
Additive gastrointestinal mucosal toxicity and nephrotoxicity, with NSAID inhibition of renal prostaglandins compounding deferasirox renal effects.
What to do
Avoid the combination where possible, particularly in patients with low platelets, renal impairment or GI history. If used, monitor renal function and blood counts and consider gastroprotection.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Nabumetone?
MediHelp rates the interaction as major. Deferasirox and Nabumetone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can cause gastrointestinal ulceration and bleeding, and deferasirox also carries risks of renal and hepatic toxicity. Combined use raises the likelihood of serious gastrointestinal hemorrhage and renal injury.
How serious is the interaction between Deferasirox and Nabumetone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible, particularly in patients with low platelets, renal impairment or GI history. If used, monitor renal function and blood counts and consider gastroprotection.
What other medicines interact with Nabumetone?
MediHelp also lists interactions of Nabumetone with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Nabumetone page.
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