Drug interactions
Deferasirox + Nisoldipine
Severity: Moderate
Deferasirox and Nisoldipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox may reduce nisoldipine concentrations since nisoldipine is a sensitive CYP3A4 substrate with high first-pass metabolism. Blood pressure control could be weaker.
What this interaction means in plain words
Deferasirox and Nisoldipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferasirox belongs to Miscellaneous; Nisoldipine belongs to Cardiovascular.
Why it happens
Possible CYP3A4 induction by deferasirox increases first-pass metabolism of nisoldipine.
What to do
Monitor blood pressure after starting or stopping deferasirox and titrate the nisoldipine dose accordingly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deferasirox
Other interactions of Nisoldipine
- Itraconazole + Nisoldipine Contraindicated
- Ketoconazole + Nisoldipine Contraindicated
- Apalutamide + Nisoldipine Major
- Carbamazepine + Nisoldipine Major
- Chloramphenicol + Nisoldipine Major
- Clarithromycin + Nisoldipine Major
Frequently asked questions
Can I take Deferasirox with Nisoldipine?
MediHelp rates the interaction as moderate. Deferasirox and Nisoldipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox may reduce nisoldipine concentrations since nisoldipine is a sensitive CYP3A4 substrate with high first-pass metabolism. Blood pressure control could be weaker.
How serious is the interaction between Deferasirox and Nisoldipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure after starting or stopping deferasirox and titrate the nisoldipine dose accordingly.
What other medicines interact with Deferasirox?
MediHelp also lists interactions of Deferasirox with, for example, Acetylsalicylic acid, Alosetron, Aluminum hydroxide. The full list is on the Deferasirox page.
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