Drug interactions
Deferasirox + Piroxicam
Severity: Major
Deferasirox and Piroxicam: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can injure the gastrointestinal mucosa, and deferasirox has been associated with GI hemorrhage and ulceration. Using them together increases the risk of serious GI bleeding, and both can also affect renal function.
What this interaction means in plain words
Deferasirox and Piroxicam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Deferasirox belongs to Miscellaneous; Piroxicam belongs to Musculoskeletal.
Why it happens
Additive gastrointestinal mucosal toxicity and bleeding tendency, with overlapping nephrotoxic potential.
What to do
Avoid concurrent use if possible; if unavoidable, give gastroprotection and monitor for GI bleeding, hemoglobin and renal function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Piroxicam?
MediHelp rates the interaction as major. Deferasirox and Piroxicam can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can injure the gastrointestinal mucosa, and deferasirox has been associated with GI hemorrhage and ulceration. Using them together increases the risk of serious GI bleeding, and both can also affect renal function.
How serious is the interaction between Deferasirox and Piroxicam?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use if possible; if unavoidable, give gastroprotection and monitor for GI bleeding, hemoglobin and renal function.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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