Drug interactions
Deferasirox + Sirolimus
Severity: Moderate
Deferasirox and Sirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox can induce CYP3A4 and may lower exposure to CYP3A4 substrates. Sirolimus blood concentrations may fall, risking reduced immunosuppression and rejection or loss of efficacy.
What this interaction means in plain words
Deferasirox and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferasirox belongs to Miscellaneous; Sirolimus belongs to Miscellaneous.
Why it happens
Deferasirox induces CYP3A4-mediated metabolism of sirolimus, increasing its clearance.
What to do
Monitor sirolimus trough concentrations when starting or stopping deferasirox and adjust the sirolimus dose to the target range.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sirolimus
- Adenovirus types 4 and 7 live + Sirolimus Contraindicated
- Bcg vaccine live + Sirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Sirolimus Contraindicated
- Ketoconazole + Sirolimus Contraindicated
- Levoketoconazole + Sirolimus Contraindicated
- Measles mumps and rubella vaccine live + Sirolimus Contraindicated
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Sirolimus?
MediHelp rates the interaction as moderate. Deferasirox and Sirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox can induce CYP3A4 and may lower exposure to CYP3A4 substrates. Sirolimus blood concentrations may fall, risking reduced immunosuppression and rejection or loss of efficacy.
How serious is the interaction between Deferasirox and Sirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sirolimus trough concentrations when starting or stopping deferasirox and adjust the sirolimus dose to the target range.
What other medicines interact with Sirolimus?
MediHelp also lists interactions of Sirolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Sirolimus page.
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