Drug interactions
Deferasirox + Tacrolimus
Severity: Moderate
Deferasirox and Tacrolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can impair renal function, so combined use raises the risk of nephrotoxicity. Deferasirox may also alter tacrolimus exposure through CYP effects.
What this interaction means in plain words
Deferasirox and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferasirox belongs to Miscellaneous; Tacrolimus belongs to Miscellaneous.
Why it happens
Additive nephrotoxicity, plus possible CYP3A4 induction by deferasirox lowering tacrolimus levels.
What to do
Monitor serum creatinine and tacrolimus trough levels regularly. Adjust the dose of either drug if renal function declines or levels change.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tacrolimus
- Adenovirus types 4 and 7 live + Tacrolimus Contraindicated
- Bcg vaccine live + Tacrolimus Contraindicated
- Cidofovir + Tacrolimus Contraindicated
- Cyclosporin + Tacrolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Tacrolimus Contraindicated
- Measles mumps and rubella vaccine live + Tacrolimus Contraindicated
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Tacrolimus?
MediHelp rates the interaction as moderate. Deferasirox and Tacrolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can impair renal function, so combined use raises the risk of nephrotoxicity. Deferasirox may also alter tacrolimus exposure through CYP effects.
How serious is the interaction between Deferasirox and Tacrolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and tacrolimus trough levels regularly. Adjust the dose of either drug if renal function declines or levels change.
What other medicines interact with Tacrolimus?
MediHelp also lists interactions of Tacrolimus with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Cidofovir. The full list is on the Tacrolimus page.
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