Drug interactions
Deferasirox + Tizanidine
Severity: Major
Deferasirox and Tizanidine: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox inhibits CYP1A2 and can raise tizanidine concentrations. Because tizanidine is a sensitive CYP1A2 substrate, this may cause marked hypotension, bradycardia and sedation.
What this interaction means in plain words
Deferasirox and Tizanidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Deferasirox belongs to Miscellaneous; Tizanidine belongs to Musculoskeletal.
Why it happens
Deferasirox inhibits CYP1A2, the main enzyme for tizanidine clearance, increasing tizanidine exposure.
What to do
Avoid concomitant use where possible, as deferasirox labeling advises against it with CYP1A2 substrates having a narrow therapeutic index. If needed, start tizanidine at a low dose and monitor blood pressure, heart rate and sedation.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Tizanidine
- Ciprofloxacin + Tizanidine Contraindicated
- Fluvoxamine + Tizanidine Contraindicated
- Pefloxacin + Tizanidine Contraindicated
- Pipemidic acid + Tizanidine Contraindicated
- Benzhydrocodone / acetaminophen + Tizanidine Major
- Brexanolone + Tizanidine Major
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Tizanidine?
MediHelp rates the interaction as major. Deferasirox and Tizanidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Deferasirox inhibits CYP1A2 and can raise tizanidine concentrations. Because tizanidine is a sensitive CYP1A2 substrate, this may cause marked hypotension, bradycardia and sedation.
How serious is the interaction between Deferasirox and Tizanidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use where possible, as deferasirox labeling advises against it with CYP1A2 substrates having a narrow therapeutic index. If needed, start tizanidine at a low dose and monitor blood pressure, heart rate and sedation.
What other medicines interact with Tizanidine?
MediHelp also lists interactions of Tizanidine with, for example, Ciprofloxacin, Fluvoxamine, Pefloxacin. The full list is on the Tizanidine page.
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