Drug interactions
Deferasirox + Zolmitriptan
Severity: Moderate
Deferasirox and Zolmitriptan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferasirox inhibits CYP1A2, the main enzyme responsible for zolmitriptan metabolism. Zolmitriptan exposure may rise, increasing triptan adverse effects such as chest tightness and blood pressure elevation.
What this interaction means in plain words
Deferasirox and Zolmitriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferasirox belongs to Miscellaneous; Zolmitriptan belongs to Central Nervous System.
Why it happens
Inhibition of CYP1A2-mediated metabolism of zolmitriptan by deferasirox.
What to do
Use the lowest effective zolmitriptan dose and avoid exceeding the maximum daily dose. Monitor blood pressure and triptan adverse effects, or choose a triptan not metabolized by CYP1A2.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Zolmitriptan
- Almotriptan + Zolmitriptan Contraindicated
- Dihydroergotamine intranasal + Zolmitriptan Contraindicated
- Dihydroergotamine + Zolmitriptan Contraindicated
- Eletriptan + Zolmitriptan Contraindicated
- Ergoloid mesylates + Zolmitriptan Contraindicated
- Ergotamine + Zolmitriptan Contraindicated
Other interactions of Deferasirox
Frequently asked questions
Can I take Deferasirox with Zolmitriptan?
MediHelp rates the interaction as moderate. Deferasirox and Zolmitriptan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferasirox inhibits CYP1A2, the main enzyme responsible for zolmitriptan metabolism. Zolmitriptan exposure may rise, increasing triptan adverse effects such as chest tightness and blood pressure elevation.
How serious is the interaction between Deferasirox and Zolmitriptan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective zolmitriptan dose and avoid exceeding the maximum daily dose. Monitor blood pressure and triptan adverse effects, or choose a triptan not metabolized by CYP1A2.
What other medicines interact with Zolmitriptan?
MediHelp also lists interactions of Zolmitriptan with, for example, Almotriptan, Dihydroergotamine intranasal, Dihydroergotamine. The full list is on the Zolmitriptan page.
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