Drug interactions
Deferiprone + Diclofenac
Severity: Moderate
Deferiprone and Diclofenac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferiprone is cleared mainly by glucuronidation via UGT1A6, which diclofenac may inhibit. Deferiprone exposure may rise, with a greater risk of adverse effects such as neutropenia.
What this interaction means in plain words
Deferiprone and Diclofenac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferiprone belongs to Miscellaneous; Diclofenac belongs to Musculoskeletal.
Why it happens
Possible inhibition of UGT1A6-mediated glucuronidation of deferiprone by diclofenac.
What to do
Monitor absolute neutrophil count as required for deferiprone therapy. Consider an alternative analgesic if there is any sign of deferiprone toxicity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Deferiprone
- Clozapine + Deferiprone Contraindicated
- Abemaciclib + Deferiprone Major
- Acalabrutinib + Deferiprone Major
- Ado-trastuzumab emtansine + Deferiprone Major
- Ado-trastuzumab + Deferiprone Major
- Aldesleukin + Deferiprone Major
Frequently asked questions
Can I take Deferiprone with Diclofenac?
MediHelp rates the interaction as moderate. Deferiprone and Diclofenac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferiprone is cleared mainly by glucuronidation via UGT1A6, which diclofenac may inhibit. Deferiprone exposure may rise, with a greater risk of adverse effects such as neutropenia.
How serious is the interaction between Deferiprone and Diclofenac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor absolute neutrophil count as required for deferiprone therapy. Consider an alternative analgesic if there is any sign of deferiprone toxicity.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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