Drug interactions
Deferiprone + Eltrombopag
Severity: Moderate
Deferiprone and Eltrombopag: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferiprone is cleared mainly by UGT1A6 glucuronidation, and eltrombopag can inhibit UGT1A6 in vitro, so deferiprone exposure might increase. Deferiprone can cause agranulocytosis, so higher exposure is of concern.
What this interaction means in plain words
Deferiprone and Eltrombopag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferiprone belongs to Miscellaneous; Eltrombopag belongs to Miscellaneous.
Why it happens
Inhibition of UGT1A6-mediated glucuronidation of deferiprone by eltrombopag.
What to do
Monitor absolute neutrophil count closely and watch for signs of infection. Reduce the deferiprone dose if neutropenia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Deferiprone
- Clozapine + Deferiprone Contraindicated
- Abemaciclib + Deferiprone Major
- Acalabrutinib + Deferiprone Major
- Ado-trastuzumab emtansine + Deferiprone Major
- Ado-trastuzumab + Deferiprone Major
- Aldesleukin + Deferiprone Major
Other interactions of Eltrombopag
- Alpelisib + Eltrombopag Moderate
- Aluminum hydroxide + Eltrombopag Moderate
- Amobarbital + Eltrombopag Moderate
- Artesunate + Eltrombopag Moderate
- Atazanavir + Eltrombopag Moderate
- Atorvastatin + Eltrombopag Moderate
Frequently asked questions
Can I take Deferiprone with Eltrombopag?
MediHelp rates the interaction as moderate. Deferiprone and Eltrombopag can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferiprone is cleared mainly by UGT1A6 glucuronidation, and eltrombopag can inhibit UGT1A6 in vitro, so deferiprone exposure might increase. Deferiprone can cause agranulocytosis, so higher exposure is of concern.
How serious is the interaction between Deferiprone and Eltrombopag?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor absolute neutrophil count closely and watch for signs of infection. Reduce the deferiprone dose if neutropenia develops.
What other medicines interact with Deferiprone?
MediHelp also lists interactions of Deferiprone with, for example, Clozapine, Abemaciclib, Acalabrutinib. The full list is on the Deferiprone page.
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