Drug interactions
Deferiprone + Probenecid
Severity: Moderate
Deferiprone and Probenecid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deferiprone is metabolized mainly by UGT1A6 to an inactive glucuronide. Probenecid may inhibit glucuronidation and raise deferiprone exposure, increasing the risk of dose-related toxicity such as neutropenia.
What this interaction means in plain words
Deferiprone and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deferiprone belongs to Miscellaneous; Probenecid belongs to Genitourinary.
Why it happens
Probenecid inhibits UGT-mediated glucuronidation of deferiprone.
What to do
Monitor absolute neutrophil count as per deferiprone labeling. Consider a lower deferiprone dose if toxicity appears.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Other interactions of Deferiprone
- Clozapine + Deferiprone Contraindicated
- Abemaciclib + Deferiprone Major
- Acalabrutinib + Deferiprone Major
- Ado-trastuzumab emtansine + Deferiprone Major
- Ado-trastuzumab + Deferiprone Major
- Aldesleukin + Deferiprone Major
Frequently asked questions
Can I take Deferiprone with Probenecid?
MediHelp rates the interaction as moderate. Deferiprone and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deferiprone is metabolized mainly by UGT1A6 to an inactive glucuronide. Probenecid may inhibit glucuronidation and raise deferiprone exposure, increasing the risk of dose-related toxicity such as neutropenia.
How serious is the interaction between Deferiprone and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor absolute neutrophil count as per deferiprone labeling. Consider a lower deferiprone dose if toxicity appears.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
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