Drug interactions
Deflazacort + Diclofenac
Severity: Moderate
Deflazacort and Diclofenac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids like deflazacort and NSAIDs like diclofenac both injure the gastric mucosa through different pathways. Taking them together raises the risk of peptic ulceration and GI bleeding.
What this interaction means in plain words
Deflazacort and Diclofenac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Diclofenac belongs to Musculoskeletal.
Why it happens
Additive pharmacodynamic gastrointestinal toxicity: NSAID prostaglandin inhibition combined with corticosteroid impairment of mucosal defense and healing.
What to do
Use the lowest effective doses for the shortest duration and add a proton pump inhibitor in patients at risk. Monitor for GI bleeding symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diclofenac
- Diclofenac + Ketorolac Contraindicated
- Diclofenac + Ketorolac intranasal Contraindicated
- Aceclofenac + Diclofenac Major
- Acemetacin + Diclofenac Major
- Alteplase + Diclofenac Major
- Amiloride + Diclofenac Major
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Diclofenac?
MediHelp rates the interaction as moderate. Deflazacort and Diclofenac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids like deflazacort and NSAIDs like diclofenac both injure the gastric mucosa through different pathways. Taking them together raises the risk of peptic ulceration and GI bleeding.
How serious is the interaction between Deflazacort and Diclofenac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest duration and add a proton pump inhibitor in patients at risk. Monitor for GI bleeding symptoms.
What other medicines interact with Diclofenac?
MediHelp also lists interactions of Diclofenac with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Diclofenac page.
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