Drug interactions
Deflazacort + Enalapril-hydrochlorothiazide
Severity: Moderate
Deflazacort and Enalapril-hydrochlorothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Deflazacort, a corticosteroid, and hydrochlorothiazide can both lower serum potassium, increasing the risk of hypokalemia and related arrhythmias. Corticosteroids can also raise blood pressure and cause fluid retention, opposing the antihypertensive effect.
What this interaction means in plain words
Deflazacort and Enalapril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Deflazacort belongs to Miscellaneous; Enalapril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive renal potassium loss from thiazide action and corticosteroid mineralocorticoid activity.
What to do
Monitor serum potassium and blood pressure, and replace potassium if needed. Use the lowest effective corticosteroid dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Deflazacort
- Adenovirus types 4 and 7 live + Deflazacort Contraindicated
- Bcg vaccine live + Deflazacort Contraindicated
- Deflazacort + Influenza virus vaccine quadrivalent intranasal Contraindicated
- Deflazacort + Measles mumps and rubella vaccine Contraindicated
- Deflazacort + Measles mumps and rubella vaccine live Contraindicated
- Deflazacort + Measles mumps rubella and varicella vaccine live Contraindicated
Frequently asked questions
Can I take Deflazacort with Enalapril-hydrochlorothiazide?
MediHelp rates the interaction as moderate. Deflazacort and Enalapril-hydrochlorothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Deflazacort, a corticosteroid, and hydrochlorothiazide can both lower serum potassium, increasing the risk of hypokalemia and related arrhythmias. Corticosteroids can also raise blood pressure and cause fluid retention, opposing the antihypertensive effect.
How serious is the interaction between Deflazacort and Enalapril-hydrochlorothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and blood pressure, and replace potassium if needed. Use the lowest effective corticosteroid dose.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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